Human/Mouse/Rat HOMER1 Alexa Fluor® 647-conjugated Antibody

Catalog #: FAB6889R Datasheet / COA / SDS

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FAB6889R-100UG

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Human/Mouse/Rat HOMER1 Alexa Fluor® 647-conjugated Antibody Summary

Species Reactivity

Human, Mouse, Rat

Specificity

Detects human HOMER1 in direct ELISAs.

Source

Monoclonal Mouse IgG2b Clone # 666241

Purification

Protein A or G purified

Immunogen

Synthetic peptide KFGQWADSRA corresponding to aa 73-82 of human HOMER1
Accession # Q86YM7

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 647 (Excitation= 650 nm, Emission= 668 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: HOMER1

HOMER1 is an approximately 48 kDa cytoplasmic protein that regulates the cell surface localization of neuronal mGluR1 and mGluR5 metabotropic glutamate receptors. It also functions in striated muscle mechanotransduction and excitation-contraction coupling by regulating the localization of transient receptor potential (TRP) channels and the coupling of ryanodine receptors to Cav1.2 calcium channels. Alternately spliced isoforms of human HOMER1 lack either the C-terminal half of the molecule (aa 178-354) or 130 aa following the WH1 domain (aa 99-228). Particular isoforms show distinct effects on hippocampal neuronal plasticity and the maintenance of extracellular glutamate levels in the prefrontal cortex. Within aa 73-82, human HOMER1 shares 100% aa sequence identity with mouse and rat HOMER1.

Long Name

Homer Protein Homolog 1

Entrez Gene IDs

9456 (Human); 26556 (Mouse)

Alternate Names

homer homolog 1 (Drosophila); HOMER; HOMER1; homer-1; HOMER1A; HOMER1B; HOMER-1B; HOMER1C; SYN47; SYN47neuronal immediate early gene, 1; Ves-1