Human/Mouse/Rat NLRP10/Pynod/NALP10 Alexa Fluor® 647-conjugated Antibody

Catalog #: FAB6606R Datasheet / COA / SDS

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FAB6606R-100UG

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Human/Mouse/Rat NLRP10/Pynod/NALP10 Alexa Fluor® 647-conjugated Antibody Summary

Species Reactivity

Human, Mouse, Rat

Specificity

Detects human NLRP10/Pynod/NALP10 in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human (rh) NALP1 (aa 1‑323), rhNALP1 (aa 1331‑1429), rhNALP2 (aa 1‑208), rhNALP3 (aa 3‑223), rhNALP3 (aa

Source

Monoclonal Mouse IgG2b Clone # 578502

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human NLRP10/Pynod/NALP10
Met386-Ile655
Accession # Q86W26

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 647 (Excitation= 650 nm, Emission= 668 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: NLRP10/Pynod/NALP10

NLRP10, also known as Pynod, NALP10, and NOD8, is a 75 kDa cytoplasmic protein that associates with the ASC component of inflammasomes. NLRP10 inhibits ASC‑dependent apoptosis, NFkB activation, and Caspase-1-dependent processing of IL-1 beta. Human NLRP10 contains one Pyrin domain (aa 1-96) and one NACHT domain (aa 167-484) but no leucine-rich repeats. Within aa 386-655, human NLRP10 shares approximately 50% aa sequence identity with mouse and rat NLRP10.

Long Name

NLR Family, Pyrin Domain Containing 10

Entrez Gene IDs

338322 (Human); 244202 (Mouse); 293426 (Rat)

Alternate Names

CLR11.1; NACHT, leucine rich repeat and PYD containing 10; NALP10; NALP10Pynod; NLR family, pyrin domain containing 10; NLRP10; NOD8; NOD8Nucleotide-binding oligomerization domain protein 8; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domaincontaining 10; PAN5; Pynod; PYNODNACHT, LRR and PYD domains-containing protein 10