Human/Mouse/Rat PINCH1 Alexa Fluor® 405-conjugated Antibody

Catalog #: FAB6257V Datasheet / COA / SDS

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FAB6257V-100UG

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Human/Mouse/Rat PINCH1 Alexa Fluor® 405-conjugated Antibody Summary

Species Reactivity

Human, Mouse, Rat

Specificity

Detects human, mouse, and rat PINCH1 in Western blots.

Source

Monoclonal Mouse IgG2b Clone # 591604

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human PINCH1
Ala2-Gly108
Accession # P48059

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 405 (Excitation= 405 nm, Emission= 421 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: PINCH1

Particularly interesting new Cys-His protein 1 (PINCH1), also known as LIMS1 (LIM and senescent cell antigen-like-containing domain protein 1), is a 37‑40 kDa, widely expressed LIM-only protein. Human PINCH1 is 325 amino acids (aa) in length and contains a tandem array of five LIM domains. Within the region used as an immunogen, human PINCH1 shares 100% and 99% aa sequence identity with mouse and rat PINCH1, respectively. PINCH1 is an effector of integrin and growth factor signaling, coupling surface receptors to downstream signaling molecules involved in the regulation of cell survival, cell proliferation and cell differentiation.

Long Name

Particularly Interesting New Cys-His Protein 1

Entrez Gene IDs

3987 (Human)

Alternate Names

LIM and senescent cell antigen-like domains 1; LIM and senescent cell antigen-like-containing domain protein 1; LIMS1; PINCH1; PINCH-1; PINCHPINCH1Particularly interesting new Cys-His protein 1; Renal carcinoma antigen NY-REN-48