Human/Mouse/Rat PKN2 Alexa Fluor® 647-conjugated Antibody

Catalog #: FAB5686R Datasheet / COA / SDS

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FAB5686R-100UG

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Human/Mouse/Rat PKN2 Alexa Fluor® 647-conjugated Antibody Summary

Species Reactivity

Human, Mouse, Rat

Specificity

Detects endogenous human, mouse and rat PKN2 in Western blots.

Source

Monoclonal Mouse IgG1 Clone # 509105

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human PKN2
Asp18-Asn207
Accession # Q16513

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 647 (Excitation= 650 nm, Emission= 668 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: PKN2

Serine/Threonine Protein Kinase N2 (PKN2), also known as PRK2, is a cytoplasmic kinase that contains three HR1 repeats (aa 44‑295), one C2 domain (aa 330‑463), and one protein kinase domain (aa 657‑916). PKN2 is a downstream effector of RhoA and promotes the activation of several kinases involved in regulation of the actin cytoskeleton, cell cycle, and apoptosis. PKN2 cleavage during apoptosis generates a C‑terminal fragment that inhibits PDK1 and Akt. PKN2 is also important in the intracellular replication of hepatitis C virus and Yersinia pestis.

Long Name

Protein Kinase N2

Entrez Gene IDs

5586 (Human); 109333 (Mouse); 207122 (Rat)

Alternate Names

cardiolipin-activated protein kinase Pak2; EC 2.7.11; EC 2.7.11.13; PAK2; Pak-2; PKN2; PRK2; PRK2MGC150606; PRKCL2; PRKCL2PRO2042; PRO2042; Protein kinase C-like 2MGC71074; protein kinase N2; Protein-kinase C-related kinase 2; serine/threonine-protein kinase N2