Human/Mouse SAM68 Antibody

SAM68 (Src associated in mitosis 68 kDa; also KH domain-containing, RNA-binding, signal transduction-associated protein 1) is a 62‑68 kDa member of the KHDRBS family of proteins. It is associated with multiple receptor systems (i.e.- TCR and leptin), as an adaptor protein by its SH2 and SH3 domains, and binds to UAAA motifs in mRNA. Human SAM68 is 443 amino acids (aa) in length. It contains one SGQ region (aa 96‑157) and one KH domain (aa 171‑197). Post‑translational modification of SAM68 alters its partnership with other molecules. For example, methylation on ArgGly motifs reduce RNA binding, acetylation on multiple Lys residues increases RNA binding, and phosphorylation on Tyr promotes SH3 domain interaction.