Human Optineurin (AAH32762.1) VersaClone cDNA

R&D Systems | Catalog # RDC3468

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Key Product Details

Species

Human

Accession Number

AAH32762.1

Background: Optineurin

Optineurin encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq]

Alternate Names

ALS12, FIP2, GLC1E, HIP7, HYPL, NRP, OPTN

Entrez Gene IDs

10133 (Human); 71648 (Mouse); 246294 (Rat)

Gene Symbol

OPTN

UniProt

AAH32762.1

Additional Optineurin Products

Product Documents for Human Optineurin (AAH32762.1) VersaClone cDNA

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Product Specific Notices for Human Optineurin (AAH32762.1) VersaClone cDNA

For research use only

Related Research Areas

Autophagy

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