Human Pannexin-2 Alexa Fluor® 405-conjugated Antibody

Catalog #: FAB7088V Datasheet / COA / SDS

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FAB7088V-100UG

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Human Pannexin-2 Alexa Fluor® 405-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human Pannexin-2 in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 5% cross-reactivity with recombinant human (rh) Pannexin-1 and no cross-reactivity with rhPannexin-3 is observed.

Source

Monoclonal Mouse IgG2b Clone # 719406

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human Pannexin-2
Arg316-Lys456
Accession # Q96RD6

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 405 (Excitation= 405 nm, Emission= 421 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Pannexin-2

Pannexin 2 (PANX2) is a ~60 kDa, 677 amino acid (aa) protein of the pannexin family of four-transmembrane channel proteins with a conserved pattern of cysteines. PANX2 can interact with PANX1. It is mainly expressed on postnatal neural progenitors and is thought to inhibit the rate of neuronal differentiation. PANX2 expression is positively correlated with survival following glioma diagnosis, and it negatively regulates glioma cell line growth. Polymorphisms of PANX2 are associated with bipolar disorder and schizophrenia. Within aa 316‑456, human PANX2 shares 96% aa sequence identity with mouse and rat PANX2. A 643 aa isoform diverges after aa 631, while a 509 aa isoform also shows an alternate start site at aa 135.

Entrez Gene IDs

56666 (Human); 406218 (Mouse); 362979 (Rat)

Alternate Names

hPANX2; MGC119432; pannexin 2; Pannexin2; Pannexin-2; PANX2; PX2