Human PDGF-B Antibody
Human PDGF-B Antibody Summary
Accession # P01127
under non-reducing conditions only
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Four PDGF family members, A, B, C and D, have been identified. PDGF-B can exist as a disulfide-linked homodimer (PDGF-BB) or heterodimer (PDGF-AB). PDGF-B binds and activates PDGF R alpha and PDGF R beta.
Citation for Human PDGF-B Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
Vascular endothelial growth factor can signal through platelet-derived growth factor receptors.
Authors: Ball SG, Shuttleworth CA, Kielty CM
J. Cell Biol., 2007-04-30;177(3):489-500.
Sample Types: Cell Lysates
Applications: Western Blot
Why are non-reducing conditions recommended for Human PDGF-B Antibody, Catalog # MAB220, in Western blot?
Catalog # MAB220 recognizes a conformational epitope on PDGF-B which can exist as a disulfide-linked homodimer (PDGF-BB) or heterodimer (PDGF-AB). Reducing conditions will break disulfide bonds and destroy the epitope the antibody recognizes. Therefore, non-reducing conditions are needed for Western Blot.
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