Human/Rat HIF-2 alpha /EPAS1 Alexa Fluor® 350-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: HIF-2 alpha/EPAS1

The hypoxia-inducible transcription factor 2 alpha (HIF-2 alpha ) is stabilized in hypoxic tissue and, similarly to HIF-1 alpha, complexes with Aryl hydrocarbon receptor nuclear translocator (ARNT). Both the HIF-1 and HIF-2 complexes bind hypoxia-response elements (HREs) in the promoters of many genes involved in adapting to an environment of insufficient oxygen or hypoxia. HIF-1 and HIF-2 do not appear completely redundant, although specific functions are only beginning to be elucidated. Hypoxic tissue environments occur in vascular and pulmonary diseases as well as cancer, which illustrates the potentially broad impact of gene regulation by both HIF-1 alpha and HIF-2 alpha.

Product Datasheets

Related Research Areas

• Basic Helix-Loop-Helix (bHLH) Transcription Factors
• Cancer Biomarkers
• Cancer Stem Cell Markers
• Cancer Stem Cell Transcription Factors
• Epigenetics
• HIF Transcription Factors
• Intracellular Signaling Molecules in Angiogenesis
• Transcription Factors in the Akt Pathway
• Transcription Regulators in VSMC
• Transcriptional Regulators in Allergy and Asthma