Human TAK1 Alexa Fluor® 405-conjugated Antibody

Catalog #: FAB5307V Datasheet / COA / SDS

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FAB5307V-100UG

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Human TAK1 Alexa Fluor® 405-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects endogenous human TAK1 in Western blots.

Source

Monoclonal Mouse IgG1 Clone # 491840

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human TAK1 isoform 1A
Met1-Ser579
Accession # Q5U0D0

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 405 (Excitation= 405 nm, Emission= 421 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: TAK1

TGF-beta-activated kinase 1 (TAK1; also MAP3K7) is a member of the STE Ser/Thr protein kinase family and the MAP kinase kinase kinase subfamily. Human TAK1 is 606 amino acids (aa) in length and contains a protein kinase domain at aa 36‑291. There are three isoforms for TAK1. Isoform 1B is the largest isoform. Isoform 1A has a 27 aa deletion corresponding to aa 404‑430 in isoform 1B, and isoform 1C has an 88 aa deletion corresponding to aa 519‑606 in isoform 1B. TAK1 activity has been implicated during TGF beta -induced and Ras-dependent tumorigenesis.

Long Name

TGF-beta activated kinase 1

Entrez Gene IDs

6885 (Human); 26409 (Mouse); 313121 (Rat)

Alternate Names

EC 2.7.11; EC 2.7.11.25; MAP3K7; MEKK7; mitogen-activated protein kinase kinase kinase 7; TAK1; TAK1/MAP3K7; TAK1TGF1a; TGF1a; TGF-beta activated kinase 1; TGF-beta-activated kinase 1; Transforming growth factor-beta-activated kinase 1