Human TLR10 Alexa Fluor® 594-conjugated Antibody

Catalog #: FAB6619T Datasheet / COA / SDS

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FAB6619T-100UG

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Human TLR10 Alexa Fluor® 594-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human TLR10 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) TLR1, 2, 3, 4, 5, 7, 8, 9, recombinant mouse (rm) TLR6, 11, 12, rhIL-1 RI, rhIL-1 RII, rhIL-1 RAcP, rhST2, rhIL-18 R, rhIL-1 Rrp2, rhIL-18 R beta, rhSIGIRR

Source

Monoclonal Mouse IgG2b Clone # 670719

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human TLR10
Asn168-Lys383
Accession # Q9BXR5

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 594 (Excitation= 590 nm, Emission= 617 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: TLR10

Toll-like receptor 10 (TLR10, CD290) is a 91-100 kDa member of the Toll-like receptor family. Human TLR10 is synthesized as a precursor with a 19 amino acid (aa) signal sequence and a 792 aa mature chain. The mature chain constitutes a single-pass type I transmembrane protein. The extracellular domain (ECD) extends from aa 20-576 and the cytoplasmic region consists of aa 598-811. Human TLR10 contains 15 leucine-rich repeats plus eight potential sites for N-linked glycosylation. In addition, it contains one cytoplasmic TIR domain. Functionally, TLR10 is involved in the innate immune response to microbial agents. Specifically, it acts via MYD88 and TRAF6, which leads to NF-kappa-B activation, cytokine secretion, and an inflammatory response. Human TLR10 shares 71% aa sequence identity with rat TLR10.

Long Name

Toll-like Receptor 10

Entrez Gene IDs

81793 (Human)

Alternate Names

CD290 antigen; CD290; MGC104967; MGC126398; MGC126399; TLR10; toll-like receptor 10