Human Tumstatin Alexa Fluor® 700-conjugated Antibody

Catalog #: FAB7546N Datasheet / COA / SDS

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FAB7546N-100UG

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Human Tumstatin Alexa Fluor® 700-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human Tumstatin in direct ELISAs. In direct ELISAs, less than 25% cross-reactivity with recombinant human Collagen IV alpha 1 is observed.

Source

Monoclonal Mouse IgG1 Clone # 762102

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human Tumstatin

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 700 (Excitation= 675-700 nm, Emission= 723 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Tumstatin

Tumstatin is a naturally occurring, anti-angiogenic, anti-tumor peptide of 28 kDa that constitutes the NC1 (non-collagenous) domain of the Collagen IV a3 chain [amino acids (aa) 1427-1670 of Coll IV a3;]. It is liberated from basement membranes by MMP-9, and interacts with Integrin aVb3 on endothelial cells, causing cell cycle arrest, or apoptosis of cells that are proliferating. Human Tumstatin is also active on mouse and bovine endothelial cells. Human Tumstatin shares 91% and 89% aa sequence identity with mouse and rat Tumstatin, respectively.

Entrez Gene IDs

1285 (Human); 12828 (Mouse)

Alternate Names

COL4A3; collagen alpha-3(IV) chain; collagen IV, alpha-3 polypeptide; collagen, type IV, alpha 3 (Goodpasture antigen); Goodpasture antigen; Tumstatin