VSIG3 (V-set and Ig domain-containing protein 3; also BT-IgSF and IGSF11) is a 52 kDa brain and testis-specific protein that belongs to the IGSF11 family of proteins. It is expressed by neurons, astrocytes and oligodendroglia. VSIG3 is an adhesion molecule that forms Ca-independent homophilic interactions in trans. Human VSIG3 is 413 amino acids (aa) in length. It is a type I transmembrane glycoprotein that contains a 219 aa extracellular domain (ECD). The ECD contains one V-type (aa 23‑136) and one C2-type Ig-like domain (aa 144‑234). Over aa 23‑245, human VSIG3 is 94% aa identical to mouse VSIG3. Two potential splice variants exist in human. Both exhibit a 16 aa substitution for the first 17 aa of the signal sequence, and one contains an additional single Ala substitution for aa 211‑235.
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Key Product Details
Species Reactivity
Applications
Label
Antibody Source
Product Specifications
Immunogen
Met1-Gly245
Accession # Q5DX21
Specificity
Clonality
Host
Isotype
Scientific Data Images for Human VSIG3 Antibody (774206)
VSIG3 Binding to VISTA/B7-H5/PD-1H by Human VISG3 Antibody.
In a functional ELISA, 0.2-2 µg/mL of this antibody will block 50% of the binding of 1 µg/mL of Recombinant Human VSIG3 Fc Chimera (Catalog # 9229-VS) to immobilized Recombinant Human VISTA/B7-H5/PD-1H Fc Chimera (Catalog # 7126-B7) coated at 1 µg/mL (100 µL/well). At 10 µg/mL, this antibody will block >90% of the binding.Applications for Human VSIG3 Antibody (774206)
Blockade of Receptor-ligand Interaction
Formulation, Preparation, and Storage
Purification
Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.
Formulation
Shipping
Stability & Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Calculators
Background: VSIG3
Long Name
Alternate Names
Gene Symbol
UniProt
Additional VSIG3 Products
Product Documents for Human VSIG3 Antibody (774206)
Certificate of Analysis
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Note: Certificate of Analysis not available for kit components.
Product Specific Notices for Human VSIG3 Antibody (774206)
For research use only
Related Research Areas
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