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IL-1 RAcP/IL-1 R3 Antibody Pair [Biotin]

Name: IL-1 RAcP/IL-1 R3 Antibody Pair [Biotin]
Brand: Novus Biologicals
SKU: NBP3-57740
Price: 899 USD
Availability: InStock

Novus Biologicals | Catalog # NBP3-57740

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Product Specifications
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Assay Type

Sandwich ELISA

Sample Type

Cell culture supernatants. Can also be used in additional biological sample types reported in the literature reported in the literature, including serum, plasma, bronchoalveolar lavage (BAL) fluid, and tissue lysates, with minor protocol modifications recommended to optimize performance across different matrices. (100 ul)

Reactivity

Ferret

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Product Specifications

Description

The ELISA kit contains a capture antibody, detection antibody, and recombinant protein standard validated for use together in an ELISA format; kit components are not supplied in matched quantities and may be purchased separately. This product is for research use only, not for use in diagnostic or therapeutic procedures, and is manufactured in the USA.

Sample Volume Required

100 ul

Conjugate

Biotin

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Storage of components varies. See protocol for specific instructions.

Background: IL-1 RAcP/IL-1 R3

Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappaB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFalpha and LPS. A serine/threonine protein kinase associated with IL-1 receptor (IRAK) and its homologue mouse pelle-like protein kinase (mPLK) were identified recently (1,2). IRAK is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response (3). IRAK mediates a signaling cascade leading to NF-kappaB activation by members in IL-1 family including IL-1 and a novel cytokine IL-18 (also termed IGIF) (1,4).

Long Name

Interleukin 1 Receptor Accessory Protein

Alternate Names

IL-1 R3, IL-1RAcP, IL1RAcP, IL1RAP

Gene Symbol

IL1RAP

Additional IL-1 RAcP/IL-1 R3 Products

Product Documents for IL-1 RAcP/IL-1 R3 Antibody Pair [Biotin]

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Certificate of Analysis

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Product Specific Notices for IL-1 RAcP/IL-1 R3 Antibody Pair [Biotin]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Antibody Pairs are guaranteed for 6 months from date of receipt.