IND 1316

Key Product Details

Product Description

IND 1316 is an activator of AMP-activated protein kinase (AMPK). In vitro, it activates AMPK in a dose-dependent manner and induces different MAPK pathways (p38 and JNK). In vivo, it reduces the neuropathological symptoms in two animal models of Huntington's Disease (nematodes and mice). It shows very low toxicity even at high concentrations (>200 μM). This compound is orally bioavailable.

Product Specifications for IND 1316

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for IND 1316

The following data is based on the product molecular weight 343.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.91 mL	14.56 mL	29.12 mL
5 mM	0.58 mL	2.91 mL	5.82 mL
10 mM	0.29 mL	1.46 mL	2.91 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Vela Neuroprotective effect of IND1316, an indole-based AMPK activator, in animal models of Huntington disease. ACS Chem.Neurosci. 2022 PMID: 34962383

Product Documents for IND 1316