JB 300

Tocris Bioscience | Catalog # 7837

Aurora A Degrader (PROTAC®)
Tocris Bioscience

Key Product Details

Description

Aurora A Degrader (PROTAC®)
View all Active Degraders »

Product Description

JB 300 is a potent and selective Aurora A Degrader (PROTAC®; DC50 = 30 nM and Dmax = 78%). It comprises a cereblon E3-ligase ligand Thalidomide (Cat. No. 0652) joined by a PEG2 linker to the Aurora A inhibitor MK-5108. The compound depletes Aurora A in MV4-11 cell lines and exhibits no degradation of Aurora B at 10 µM. JB 300 shows dose-dependent cytotoxicity in AML cells.

Aurora A antibodies validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # AF3295 and NBP1-51843.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Licensing Information

Sold under license from University of Würzburg

Product Specifications for JB 300

Molecular Weight

906.38

Formula

C43H45ClFN7O10S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

trans-4-(3-Chloro-2-fluorophenoxy)-N-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)ethoxy)ethoxy)ethyl)-1-((6-(thiazol-2-ylamino)pyridin-2-yl)methyl)cyclohexane-1-carboxamide

CAS Number

3038446-90-8

InChI Key

LAZHTWDJEQSMOY-NKEKBGIASA-N

SMILES

O=C([C@@]1(CC2=CC=CC(NC3=NC=CS3)=N2)CC[C@H](OC4=C(F)C(Cl)=CC=C4)CC1)NCCOCCOCCNC(COC5=C6C(N(C7CCC(NC7=O)=O)C(C6=CC=C5)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 18.13 20

Preparing Stock Solutions for JB 300

The following data is based on the product molecular weight 906.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 5.52 mL 27.58 mL 55.16 mL
1 mM 1.10 mL 5.52 mL 11.03 mL
2 mM 0.55 mL 2.76 mL 5.52 mL
10 mM 0.11 mL 0.55 mL 1.10 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for JB 300

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for JB 300

For research use only

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