K 858

Key Product Details

Product Description

K 858 is a selective ATP-uncompetitive mitotic kinesin Eg5 inhibitor (IC₅₀ = 1.3 μM). Induces mitotic arrest, caspase-3 activation and cell growth inhibition in HCT116 cells. Displays no effect on microtubule dynamics. Preferentially induces mitotic arrest in cancer cells.

Product Specifications for K 858

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for K 858

The following data is based on the product molecular weight 277.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.61 mL	18.03 mL	36.06 mL
5 mM	0.72 mL	3.61 mL	7.21 mL
10 mM	0.36 mL	1.80 mL	3.61 mL
50 mM	0.07 mL	0.36 mL	0.72 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Nakai K858, a novel inhibitor of mitotic kinesin Eg5 and antitumor agent, induces cell death in cancer cells. Cancer Res. 2009 PMID: 19351824

Product Documents for K 858