KN-62

Tocris Bioscience | Catalog # 1277

Non-competitive P2X7 antagonist
Tocris Bioscience

Key Product Details

Description

Non-competitive P2X7 antagonist
View all P2X Receptor Antagonists »

Product Description

KN-62 is a selective, cell-permeable inhibitor of CaM kinase II (IC50 = 0.9 μM). Binds directly to the calmodulin binding site of the enzyme. Potent non-competitive antagonist at the P2X7 receptor (IC50 = 15 nM).

Product Specifications for KN-62

Molecular Weight

721.84

Formula

C38H35N5O6S2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

4-[(2S)-2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl] phenyl isoquinolinesulfonic acid ester

CAS Number

127191-97-3

PubChem ID

5312126

InChI Key

RJVLFQBBRSMWHX-DHUJRADRSA-N

SMILES

O=S(C1=CC=CC2=C1C=CN=C2)(N(C)[C@H](C(N4CCN(C7=CC=CC=C7)CC4)=O)CC3=CC=C(OS(C5=CC=CC6=C5C=CN=C6)(=O)=O)C=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 72.18 100

Preparing Stock Solutions for KN-62

The following data is based on the product molecular weight 721.84.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.39 mL 6.93 mL 13.85 mL
5 mM 0.28 mL 1.39 mL 2.77 mL
10 mM 0.14 mL 0.69 mL 1.39 mL
50 mM 0.03 mL 0.14 mL 0.28 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 169 publications citing the usage of this product.

Product Documents for KN-62

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for KN-62

For research use only

Customer Reviews for KN-62 (1)

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  • KN62 treatment
    Name: Xiaoyu Zhang
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: neuron cells
    Verified Customer | Posted 02/07/2024
    Mouse neuron culture treated with 10nM KN62. MAP staining showed after treatment.
    KN-62 1277

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