LIH 383

Tocris Bioscience | Catalog # 8095

Atypical chemokine receptor (ACKR3) agonist
Tocris Bioscience

Key Product Details

Description

Atypical chemokine receptor (ACKR3) agonist
View all Chemokine Receptor Agonists »

Product Description

LIH 383 is a potent and highly selective atypical chemokine receptor (ACKR3/CXCR7) agonist. LIH 383 competes directly with CXCL12-AF647 and is more potent in inducing β-arrestin recruitment to ACKR3 (EC50 = 0.61 nM) than the full-length chemokine ligands CXCL12 or CXCL11 (EC50 values are 1.2 nM and 2.2 nM, respectively). In a rat ex vivo model, LIH 383 increases the availability and signaling of opioid peptides at classical receptors.

Licensing Information

Sold under patent license from Luxembourg Institute of Health.

Product Specifications for LIH 383

Molecular Weight

997.23

Formula

C45H72N16O8S

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

2866266-58-0

InChI Key

HKVZPBVWPFDBBQ-LBBUGJAGSA-N

SMILES

O=C(NCC(NCC(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCSC)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N)=O)=O)=O)=O)=O)=O)=O)[C@H](CC2=CC=CC=C2)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 2mg/ml in water

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Background References

References are publications that support the biological activity of the product.

Product Documents for LIH 383

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for LIH 383

For research use only

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