Macbecin I

Tocris Bioscience | Catalog # 3061

Hsp90 inhibitor
Tocris Bioscience
Discontinued Product
3061 has been discontinued. View all HSP90 Inhibitors products.

Key Product Details

Description

Hsp90 inhibitor
View all HSP90 Inhibitors »

Product Description

Macbecin I is an ansamycin antibiotic compound that inhibits Hsp90 activity (IC50 = 2 μM) by binding to the ATP-binding site. Exhibits antitumor and cytocidal activities (IC50 ~ 0.4 μM) by causing degradation of key oncogenic client proteins such as ErbB2 and cRaf1. Displays higher affinity and potency than geldanamycin (Cat. No. 1368).

Product Specifications for Macbecin I

Molecular Weight

558.67

Formula

C30H42N2O8

Storage

Desiccate at -20°C

Chemical Name

(15R)-6,17-Didemethoxy-15-methoxy-6-methyl-11-O-methyl-geldanamycin

CAS Number

73341-72-7

PubChem ID

6436263

InChI Key

PLTGBUPHJAKFMA-HXUNTIRESA-N

SMILES

O=C1C=C([C@H](OC)[C@@H](C)C[C@H](OC)[C@H](OC)[C@@H](C)/C=C(C)/[C@H](OC(N)=O)[C@@H](C)/C=C/C=C(C)/C2=O)C(C(N2)=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 18 publications citing the usage of this product.

Product Documents for Macbecin I

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Macbecin I

For research use only

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