MAD4 Antibody

Novus Biologicals | Catalog # NB100-1117

Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

Western Blot, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG
View all MAD4 Primary Antibodies »

Product Specifications

Immunogen

Peptide with sequence GPHCRRLGRPALS corresponding to C-Terminus according to NP_006445.1.

Localization

Nuclear

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for MAD4 Antibody

Western Blot: MAD4 Antibody [NB100-1117]

Western Blot: MAD4 Antibody [NB100-1117]

Western Blot: MAD4 Antibody [NB100-1117] - (0.5 ug/ml) of human kidney lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence

Applications for MAD4 Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:16000

Western Blot

0.5 - 2 ug/ml
Application Notes
WB: Approx. 22 kDa band observed in human kidney lysates (predicted MW of 24 kDa band according to NP_006445). Please note the appearance of this band was blocked by incubation with the immunizing peptide.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: MAD4

This gene is a member of the MAD gene family. The MAD genes encode basic helix loop helix leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues.

Alternate Names

BHLHC12, bHLHc12Max-interacting transcriptional repressor MAD4, Class C basic helix-loop-helix protein 12, Mad4 homolog, MAD4Max-associated protein 4, MAX dimerization protein 4, Max dimerizer 4, MST149, MSTP149, MXD4 MAX dimerization protein 4

Entrez Gene IDs

10608 (Human)

Gene Symbol

MXD4

UniProt

NP_006445. (Human)

Additional MAD4 Products

Product Documents for MAD4 Antibody

Certificate of Analysis

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Product Specific Notices for MAD4 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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FAQs

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