Marimastat

Tocris Bioscience | Catalog # 2631

Broad spectrum MMP inhibitor
Tocris Bioscience

Key Product Details

Description

Broad spectrum MMP inhibitor

Alternative Names

BB 2516,Marimistat
View all Synthetic Metalloprotease Inhibitors »

Product Description

Marimastat is a broad spectrum inhibitor of MMPs (IC50 values are 3, 5, 6, 9 and 13 nM for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 respectively). Inhibits peritoneal dissemination of human gastric cancer cells in vivo through inhibition of tumor angiogenesis.

Product Specifications for Marimastat

Molecular Weight

331.41

Formula

C15H29N3O5

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(2S,3R)-N4-[(1S)-2,2-Dimethyl-1-[(methylamino)carbonyl]propyl]-N1,2-dihydroxy-3-(2-methylpropyl)butanediamide

CAS Number

154039-60-8

PubChem ID

119031

InChI Key

OCSMOTCMPXTDND-OUAUKWLOSA-N

SMILES

O=C(NO)[C@@H](O)[C@H]([C@](N[C@@H]([C@](C)(C)C)C(NC)=O)=O)CC(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.14 100

Preparing Stock Solutions for Marimastat

The following data is based on the product molecular weight 331.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.02 mL 15.09 mL 30.17 mL
5 mM 0.60 mL 3.02 mL 6.03 mL
10 mM 0.30 mL 1.51 mL 3.02 mL
50 mM 0.06 mL 0.30 mL 0.60 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 100 publications citing the usage of this product.

Product Documents for Marimastat

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Marimastat

For research use only

Customer Reviews for Marimastat (1)

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  • great product
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Hippocampal neuron
    Verified Customer | Posted 03/26/2020
    matrix metalloproteinases 1, 2, 3, 7, 9, 14, and 17 (0.1–1 μM batimastat and marimastat)
    Marimastat 2631

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