Melphalan

Key Product Details

Product Description

Melphalan is a DNA alkylating agent; induces cytotoxicity through the formation of stable interstrand and intrastrand crosslinks within DNA. Inhibits growth of PC-3 cells (IC₅₀ values are 0.074 and 0.77 μg/ml for sequential dosing and single dosing respectively).

Product Specifications for Melphalan

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Melphalan

The following data is based on the product molecular weight 305.20.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	16.38 mL	81.91 mL	163.83 mL
1 mM	3.28 mL	16.38 mL	32.77 mL
2 mM	1.64 mL	8.19 mL	16.38 mL
10 mM	0.33 mL	1.64 mL	3.28 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Bauer and Povirk Specificity and kinetics of interstrand and intrastrand bifunctional alkylation by nitrogen mustards at a G-G-C sequence. Nucleic Acids Res. 1997 PMID: 9092631
• Mougenot In vitro cytotoxic effect of melp. and pilot phase II study in hormone-refractory prostate cancer. Anticancer Res. 2006 PMID: 16821586
• Blumberg An alkylating agent for multiple myeloma: melp. JAMA. 1965 PMID: 14239026

Product Documents for Melphalan