(-)-Bicuculline methiodide

Tocris Bioscience | Catalog # 2503

GABAA antagonist; more water soluble version of (+)-bicuculline (Cat. No. 0130)
Tocris Bioscience

Key Product Details

Description

GABAA antagonist; more water soluble version of (+)-bicuculline (Cat. No. 0130)
View all GABA-A Receptor Antagonists »

Product Description

(-)-Bicuculline methiodide is a methiodide form of classical GABAA receptor antagonist (+)-bicuculline. More water-soluble and stable. Non-GABA receptor-mediated actions reported, including actions on calcium-dependent potassium channels.

Methobromide Salt and Methochloride Salt also available.

Product Specifications for (-)-Bicuculline methiodide

Molecular Weight

509.30

Formula

C21H20INO6

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

[R-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium iodide

CAS Number

40709-69-1

PubChem ID

104871

InChI Key

HKJKCPKPSSVUHY-GRTNUQQKSA-M

SMILES

[H][C@](C(C=CC6=C5OCO6)=C5C(O4)=O)4[C@]2([H])C1=CC3=C(OCO3)C=C1CC[N+](C)2C.[I-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 10.19 20
DMSO 25.46 50

Preparing Stock Solutions for (-)-Bicuculline methiodide

The following data is based on the product molecular weight 509.30.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.93 mL 19.63 mL 39.27 mL
2.5 mM 0.79 mL 3.93 mL 7.85 mL
5 mM 0.39 mL 1.96 mL 3.93 mL
25 mM 0.08 mL 0.39 mL 0.79 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 370 publications citing the usage of this product.

Product Documents for (-)-Bicuculline methiodide

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for (-)-Bicuculline methiodide

For research use only

Related Research Areas

GABA Receptors

Citations for (-)-Bicuculline methiodide

Customer Reviews for (-)-Bicuculline methiodide (3)

4.3 out of 5
3 Customer Ratings
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3 Stars
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  • reliable product
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Sprague-Dawley rats primary neuronal
    Verified Customer | Posted 04/04/2020
    We increased synaptic activity using a standard pharmacological approach (20 μM bicuculline and 100 μM 4-AP.
    (-)-Bicuculline methiodide 2503
  • Antidepressantsby Cholecystokinin Neurons of the Dentate Gyrus
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vivo
    Verified Customer | Posted 02/03/2020
    1mM Bicuculline
    (-)-Bicuculline methiodide 2503
  • Bicuculline methiodide as a test tool of GABA-A receptor pharmacological properties
    Name: Sergiy Sylantyev
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Human embryo kidney cells
    Verified Customer | Posted 08/31/2019
    Bicuculline methiodide (Bic) was used to test GABA-A receptors pharmacological properties after expression in pre-transfected HEK cells. 100 microM of Bic fullu suppressed chloride current generated by application of 50 microM GABA at outside-out membrane patch. Figure: black trace - application of GABA, grey trace - application of GABA+Bic.
    (-)-Bicuculline methiodide 2503

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