(+)-Bicuculline

Tocris Bioscience | Catalog # 0130

Potent GABAA antagonist
Tocris Bioscience

Key Product Details

Description

Potent GABAA antagonist
View all GABA-A Receptor Antagonists »

Product Description

(+)-Bicuculline is a classical GABAA antagonist.

Methoiodide Salt, Methobromide Salt and Methochloride Salt also available.

Product Specifications for (+)-Bicuculline

Molecular Weight

367.36

Formula

C20H17NO6

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

[R-(R*,S*)]-6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)furo[3,4-e]-1,3-benzodioxol-8(6H)-one

CAS Number

485-49-4

PubChem ID

10237

InChI Key

IYGYMKDQCDOMRE-ZWKOTPCHSA-N

SMILES

[H][C@](C(C=CC6=C5OCO6)=C5C(O4)=O)4[C@]2([H])C1=CC3=C(OCO3)C=C1CCN2C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.74 100

Preparing Stock Solutions for (+)-Bicuculline

The following data is based on the product molecular weight 367.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.72 mL 13.61 mL 27.22 mL
5 mM 0.54 mL 2.72 mL 5.44 mL
10 mM 0.27 mL 1.36 mL 2.72 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 1042 publications citing the usage of this product.

Product Documents for (+)-Bicuculline

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for (+)-Bicuculline

For research use only

Related Research Areas

GABA Receptors

Citations for (+)-Bicuculline

Customer Reviews for (+)-Bicuculline (1)

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  • Use of BIC as a selective GABA-A receptor antagonist
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Hippocampus
    Verified Customer | Posted 05/20/2019
    We have used (+)-Bicuculline (BIC) as a control tool to make sure that only GABA-A receptors are active under perfusion with given set of neuroreceptor antagonists. Being applied at membrane patches excised from cerebellar granule cell, 10 microM GABA triggered clear single-channel openings of GABA-A receptors. However, 100 microM BIC added together with GABA completely suppressed all single-channel activity, thus proving absence of other receptor types.
    (+)-Bicuculline 0130

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