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Mouse CXCL7/Thymus Chemokine-1 Antibody

Catalog #: MAB1091
1 Citation Datasheet / COA / SDS
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MAB1091
MAB1091-SP

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Chemotaxis Induced by CXCL7/Thymus Chemokine‑1 and Neutralization by Mouse CXCL7/Thymus Chemokine‑1 Antibody.
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Mouse CXCL7/Thymus Chemokine-1 Antibody Summary

Species Reactivity
Mouse
Specificity
Detects mouse CXCL7/Thymus Chemokine‑1 in direct ELISAs. In direct ELISAs, no cross‑reactivity with recombinant human (rh) CXCL1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 16, recombinant mouse (rm) CXCL1, 4, 6, 9, 10, 11, 12, 13, 15, 16, recombinant rat (rr) CXCL1, 2, 3, 5, recombinant porcine CXCL8, or recombinant cotton rat CXCL10 is observed.
Source
Monoclonal Rat IgG2B Clone # 159742
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
E. coli-derived recombinant mouse CXCL7/Thymus Chemokine‑1
Lys40-Tyr113
Accession # Q9EQI5
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Endotoxin Level
<0.10 EU per 1 μg of the antibody by the LAL method.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
Recombinant Mouse CXCL7/Thymus Chemokine-1 (Catalog # 793-CK) under non-reducing conditions only
Neutralization
Measured by its ability to neutralize CXCL7/Thymus Chemokine‑1-induced chemotaxis in the BaF3 mouse pro‑B cell line transfected with human CXCR2. The Neutralization Dose (ND50) is typically 2-8 µg/mL in the presence of 40 ng/mL Recombinant Mouse CXCL7/Thymus Chemokine‑1 aa 48‑109.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Neutralization Chemotaxis Induced by CXCL7/Thymus Chemokine‑1 and Neutralization by Mouse CXCL7/Thymus Chemokine‑1 Antibody. View Larger

Chemotaxis Induced by CXCL7/Thymus Chemokine‑1 and Neutralization by Mouse CXCL7/Thymus Chemokine‑1 Antibody. Recombinant Mouse CXCL7/Thymus Chemokine‑1 aa 48‑109 (Catalog # 1091-CK) chemoattracts the BaF3 mouse pro‑B cell line transfected with human CXCR2 in a dose-dependent manner (orange line). The amount of cells that migrated through to the lower chemotaxis chamber was measured by Resazurin (Catalog # AR002). Chemotaxis elicited by Recombinant Mouse CXCL7/Thymus Chemokine‑1 aa 48‑109 (40 ng/mL) is neutralized (green line) by increasing concentrations of Rat Anti-Mouse CXCL7/Thymus Chemokine‑1 Monoclonal Antibody (Catalog # MAB1091). The ND50 is typically 2-8 µg/mL.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: CXCL7/Thymus Chemokine-1

CXCL7 is a member of the alpha (CXC) subfamily of chemokines. Mouse CXCL7 cDNA encodes a 113 amino acid precursor protein that shares 72% amino acid sequence identity with rat CXCL7.

Entrez Gene IDs
57349 (Mouse); 246358 (Rat)
Alternate Names
Beta-TG;B-TG1;CTAP3;CTAPIII;CTAP-III;CXCL7;LA-PF4;LDGF;MDGF;NAP-2;PBP;Platelet basic protein;PPBP;SCYB7;TC1;TC2;TGB;TGB1;THBGB;THBGB1; Thymus Chemokine1; Thymus Chemokine-1

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Citation for Mouse CXCL7/Thymus Chemokine-1 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1

  1. IFN?-induced BST2+ tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling
    Authors: Zheng, C;Wang, J;Zhou, Y;Duan, Y;Zheng, R;Xie, Y;Wei, X;Wu, J;Shen, H;Ye, M;Kong, B;Liu, YH;Xu, P;Zhang, Q;Liang, T;
    Cell reports
    Species: Mouse, Transgenic Mouse
    Sample Types: In Vivo
    Applications: Neutralization

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