NAIP-1 (Neuronal Apoptosis Inhibitory Protein 1; also Naip and Birc1) is a 150-160 kDa member of both the NLR/PRR and IAP family of proteins. It is widely, but not ubiquitously expressed, and is found in adipocytes, macrophages, neurons, renal proximal and distal convoluted tubules, and nonproliferative intestinal epithelium. NAIP-1 plays a key regulatory role in caspase activation. It promotes caspase-1 activation, blocks caspase-3 and -7 activation, and by binding neuronal hippocalcin, inhibits caspase-3-independent apoptosis. Mouse NAIP-1 is 1403 amino acids (aa) in length. It contains three consecutive N-terminal BIR (Baculovirus Inhibition of apoptosis Repeat) domains (aa 63-346) and one NACHT region (aa 464-758). The BIR #2 domain is posited to bind both caspase-3 and -7, while the BIR domain #3 likely interacts with hippocalcin. NAIP-1 undergoes proteolysis, generating an N-terminal 100 kDa fragment (likely aa 1- ≈ 869) and a 60 kDa C-terminal fragment (likely aa 870-1403). The C-terminal fragment undergoes further processing to generate a 25 kDa and 35 kDa fragment. There are at least seven numbered NAIP genes in mouse that have arisen by gene duplication. Over the aa range 783-856, they share less than 60% aa sequence identity with NAIP-1. Over the same aa range, mouse NAIP-1 shares 54% aa sequence identity with the only human NAIP gene.
Mouse NAIP Alexa Fluor® 750‑conjugated Antibody
R&D Systems | Catalog # AF7608S
Key Product Details
Species Reactivity
Applications
Label
Antibody Source
Product Specifications
Immunogen
Lys783-Ser856
Accession # Q9QWK5
Specificity
Clonality
Host
Isotype
Applications for Mouse NAIP Alexa Fluor® 750‑conjugated Antibody
Western Blot
Formulation, Preparation, and Storage
Purification
Formulation
Shipping
Stability & Storage
Background: NAIP
Long Name
Alternate Names
Gene Symbol
UniProt
Additional NAIP Products
Product Documents for Mouse NAIP Alexa Fluor® 750‑conjugated Antibody
Product Specific Notices for Mouse NAIP Alexa Fluor® 750‑conjugated Antibody
This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.
For research use only
Related Research Areas
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