Key Product Details

Species Reactivity

Mouse

Applications

Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Rat IgG2B Clone # 209126
View all Serpin F2/alpha 2-Antiplasmin Primary Antibodies »

Product Specifications

Immunogen

Mouse myeloma cell line NS0-derived recombinant mouse Serpin F2/ alpha 2‑Antiplasmin
Val28-Lys491
Accession # Q61247

Specificity

Detects mouse Serpin F2/ alpha

Clonality

Monoclonal

Host

Rat

Isotype

IgG2B

Applications for Mouse Serpin F2/ alpha 2‑Antiplasmin Antibody

Application
Recommended Usage

Western Blot

1 µg/mL
Sample: Recombinant Mouse Serpin F2/ alpha 2‑Antiplasmin (Catalog # 1239-PI)

Reviewed Applications

Read 1 review rated 5 using MAB1239 in the following applications:

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Calculators

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background: Serpin F2/alpha 2-Antiplasmin

Serpin F2 is a member of the Serpin superfamily and the primary physiological inhibitor of the serine protease plasmin, which is responsible for the dissolution of fibrin clots (1, 2). In addition to plasmin, Serpin F2 is also an efficient inhibitor of trypsin and chymotrypsin (3). Liver and kidney are major sites of Serpin F2 production and other tissues such as muscle, intestine, central nervous system, and placenta also express its mRNA at a moderate level (3). The tissue expression pattern of Serpin F2 indicates that it is a key regulator of plasmin-mediated proteolysis in these tissues. Mouse Serpin F2 is synthesized as a 491 amino acid precursor with a 27 amino acid signal peptide. The secreted protein has a short propeptide (residues 28 to 39) and a mature chain (residues 40 to 491). For human Serpin F2, the presence of the propeptide did not affect its ability to inhibit plasmin but reduced its cross-linking ability to fibrin (4).

References

  1. Menoud, P.-A. et al. (1996) J. Clin. Invest. 97:2478.
  2. Silverman, G.A. et al. (2001) J. Biol. Chem. 276:33293.
  3. Potempa, J. et al. (1988) Science. 241:699.
  4. Sumi, Y. et al. (1989) J. Biochem. 106:703.

Alternate Names

alpha 2-Antiplasmin

Entrez Gene IDs

5345 (Human); 18816 (Mouse)

Gene Symbol

SERPINF2

UniProt

Q61247

Additional Serpin F2/alpha 2-Antiplasmin Products

Product Documents for Mouse Serpin F2/ alpha 2‑Antiplasmin Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Note: Certificate of Analysis not available for kit components.

Download SDS

Product Specific Notices for Mouse Serpin F2/ alpha 2‑Antiplasmin Antibody

For research use only

Customer Reviews (1)

5 out of 5
1 Customer Rating
5 Stars
100%
4 Stars
0%
3 Stars
0%
2 Stars
0%
1 Stars
0%

Have you used Mouse Serpin F2/ alpha 2‑Antiplasmin Antibody?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card

Customer Images

Showing  1 - 1 的 1 review Showing All
Filter By:
Clear Filters X
  • Mouse Serpin F2/ alpha 2-Antiplasmin Antibody
    Name: Anonymous
    Application: Western Blot
    Sample Tested: Plasma
    Species: Mouse
    Verified Customer | Posted 08/23/2019
    Mouse Serpin F2/ alpha 2‑Antiplasmin Antibody MAB1239

There are no reviews that match your criteria.

Showing  1 - 1 的 1 review Showing All

FAQs

No product specific FAQs exist for this product.

View all FAQs for Antibodies

Associated Pathways

Blood Coagulation Signaling Pathways Blood Coagulation Signaling Pathway Thumbnail