MS 28

Tocris Bioscience | Catalog # 8076

Cyclin D1, CDK4/6 and cyclin D3 Degrader (PROTAC®)
Tocris Bioscience

Key Product Details

Description

Cyclin D1, CDK4/6 and cyclin D3 Degrader (PROTAC®)
View all Active Degraders »

Product Description

MS 28 is a cyclinD1 Degrader (PROTAC®) (DC50 = 950 nM; Dmax = 90% in vitro). Also degrades CDK4, CDK6 and cyclin D3 after 4 hours. Degrades cyclin D1 and cyclin D3 by recruiting the CDK4/6 as a 'bridge'. Comprises a CDK4/6 binding moiety joined by a linker to a VHL ligand. Suppresses NCI-H2110 and Calu-1 cancer cell growth at 1 μM.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Licensing Information

Sold under license from Icahn School of Medicine at Mount Sinai.

Product Specifications for MS 28

Molecular Weight

1002.25

Formula

C53H67N11O7S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(2S,4R)-1-((S)-2-(7-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)-7-oxoheptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

CAS Number

2229974-73-4

PubChem ID

146014438

InChI Key

MWVNDEBEHBRZEC-WWTLGBROSA-N

SMILES

O=C1N(C2CCCC2)C3=NC(NC4=CC=C(N5CCN(CC5)C(CCCCCC(N[C@@H](C(C)(C)C)C(N6[C@@H](C[C@H](C6)O)C(NCC7=CC=C(C8=C(C)N=CS8)C=C7)=O)=O)=O)=O)C=N4)=NC=C3C(C)=C1C(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 100.22 100

Preparing Stock Solutions for MS 28

The following data is based on the product molecular weight 1002.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.00 mL 4.99 mL 9.98 mL
5 mM 0.20 mL 1.00 mL 2.00 mL
10 mM 0.10 mL 0.50 mL 1.00 mL
50 mM 0.02 mL 0.10 mL 0.20 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for MS 28

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for MS 28

For research use only

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