Nateglinide

Key Product Details

Product Description

Nateglinide is a k_ir6 (K_ATP) blocker. Exhibits in vitro tissue selectivity for pancreatic β-cell-type K_ir6 channels over cardiovascular K_ir6 channels; displays high affinity for SUR1/K_ir6.2 channels. Hypoglycemic agent; stimulates insulin secretion from pancreatic β-cells by increasing cytosolic Ca²⁺ concentration. Also agonist at the orphan receptor MRGPRX4.

Product Specifications for Nateglinide

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Nateglinide

The following data is based on the product molecular weight 317.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.15 mL	15.75 mL	31.50 mL
5 mM	0.63 mL	3.15 mL	6.30 mL
10 mM	0.32 mL	1.58 mL	3.15 mL
50 mM	0.06 mL	0.32 mL	0.63 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Kroeze PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome. Nat.Struct.Mol.Biol. 2015 PMID: 25895059
• Chachin Nateglinide, a D-phenylalanine derivative lacking either a sulfonylurea or benzamido moiety, specifically inhibits pancreatic β-cell-type K_ATP channels. J.Pharmacol.Exp.Ther. 2003 PMID: 12604678
• Fujitani The ability of a new hypoglycemic agent, A-4166, compared to sulphonylureas, to increase cytosolic Ca²⁺ in pancreatic beta-cells under metabolic inhibition. Br.J.Pharmacol. 1997 PMID: 9105692
• Hu Tissue selectivity of antidiabetic agent nateglinide: study on cardiovascular and β-cell K_ATP channels. J.Pharmacol.Exp.Ther. 1999 PMID: 10565863
• Shinkai N-(cyclohexylcarbonyl)-D-phenylalanines and related compounds. A new class of hypoglycemic agents. J.Med.Chem. 1989 PMID: 2738878

Product Documents for Nateglinide