NF 023

Tocris Bioscience | Catalog # 1240

Selective and competitive P2X1 antagonist
Tocris Bioscience

Key Product Details

Description

Selective and competitive P2X1 antagonist
View all P2X Receptor Antagonists »

Product Description

NF 023 is an a subtype-selective, competitive and reversible P2X1 receptor antagonist. Displays IC50 values of 0.21, 28.9, > 50 and > 100 μM for human P2X1, P2X3, P2X2, and P2X4-mediated responses respectively. Selective over adrenoceptors, histamine and P2Y receptors. Also selectively inhibits the α-subunit of Go/i (EC50 ~300 nM). Also inhibits DNA-binding activity of HMGA2 (IC50 = 10.63 μM).

Product Specifications for NF 023

Molecular Weight

1162.86

Formula

C35H20N4Na6O21S6

Storage

Desiccate at RT

Chemical Name

8,8'-[carbonylbis(imino-3,1-phenylenecarbonylimino)]bis-1,3,5-naphthalene-trisulphonic acid, hexasodium salt

CAS Number

104869-31-0

PubChem ID

4465

InChI Key

FMQURVHYTBGYSQ-UHFFFAOYSA-H

SMILES

[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[O-]S(=O)(=O)C1=CC2=C(C=CC(NC(=O)C3=CC=CC(NC(=O)NC4=CC(=CC=C4)C(=O)NC4=C5C(C=C(C=C5S([O-])(=O)=O)S([O-])(=O)=O)=C(C=C4)S([O-])(=O)=O)=C3)=C2C(=C1)S([O-])(=O)=O)S([O-])(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 100

Preparing Stock Solutions for NF 023

The following data is based on the product molecular weight 1162.86.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.86 mL 4.30 mL 8.60 mL
5 mM 0.17 mL 0.86 mL 1.72 mL
10 mM 0.09 mL 0.43 mL 0.86 mL
50 mM 0.02 mL 0.09 mL 0.17 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 40 publications citing the usage of this product.

Product Documents for NF 023

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for NF 023

For research use only

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