NF 110

Tocris Bioscience | Catalog # 2548

Potent P2X3 antagonist
Tocris Bioscience

Key Product Details

Description

Potent P2X3 antagonist
View all P2X Receptor Antagonists »

Product Description

NF 110 is a high affinity P2X3 receptor antagonist (Ki values are 36, 82 and 4144 nM for P2X3, P2X1 and P2X2 recombinant receptors respectively). Shows no activity at P2Y1, P2Y2 and P2Y11 receptors (IC50 > 10 μM). Potently inhibits α,β-meATP-evoked desensitizing currents in rat DRG neurons (IC50 = 527 nM). Shows antitumor activity against several tumor types. Also inhibits DNA-binding activity of HMGA2 (IC50 = 0.87 μM).

This product is supplied with a high degree of hydration and some residual NaCl, the amount of which are batch dependent. Please refer to the Certificate of Analysis to obtain the batch specific Net Product Content.

Product Specifications for NF 110

Molecular Weight

1096.90

Formula

C41H28N6Na4O17S4

Storage

Desiccate at RT

Purity

≥90% (HPLC)

Chemical Name

4,4',4'',4'''-[Carbonylbis[imino-5,1,3-benzenetriylbis(carbonylimino)]]tetrakisbenzenesulfonic acid tetrasodium salt

CAS Number

111150-22-2

PubChem ID

16066783

InChI Key

AQJHZNCSXLBXMY-UHFFFAOYSA-J

SMILES

[Na+].[Na+].[Na+].[Na+].[O-]S(=O)(=O)C1=CC=C(NC(=O)C2=CC(=CC(NC(=O)NC3=CC(=CC(=C3)C(=O)NC3=CC=C(C=C3)S([O-])(=O)=O)C(=O)NC3=CC=C(C=C3)S([O-])(=O)=O)=C2)C(=O)NC2=CC=C(C=C2)S([O-])(=O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 40 37

Preparing Stock Solutions for NF 110

The following data is based on the product molecular weight 1096.90.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.37 mM 2.46 mL 12.32 mL 24.64 mL
1.85 mM 0.49 mL 2.46 mL 4.93 mL
3.7 mM 0.25 mL 1.23 mL 2.46 mL
18.5 mM 0.05 mL 0.25 mL 0.49 mL

Calculators

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Product Documents for NF 110

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for NF 110

For research use only

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