NF 157

Tocris Bioscience | Catalog # 2450

Selective P2Y11 and P2X1 antagonist
Tocris Bioscience

Key Product Details

Description

Selective P2Y11 and P2X1 antagonist
View all P2X Receptor Antagonists »

Product Description

NF 157 is a purinergic receptor antagonist that potently inhibits P2Y11 receptor activity (IC50 = 463 nM). Displays selectivity for P2Y11 and P2X1 receptors over P2Y1, P2Y2, P2X2, P2X3, P2X4 and P2X7 receptors. Inhibits NAD+-induced activation of human granulocytes.

This product is supplied with a high degree of hydration and some residual NaCl, the amount of which are batch dependent. Please refer to the Certificate of Analysis to obtain the batch specific Net Product Content and the maximum solubility threshold to use in dilution calculations.

Product Specifications for NF 157

Molecular Weight

1437.08

Formula

C49H28F2N6Na6O23S6

Storage

Desiccate at RT

Purity

≥90% (HPLC)

Chemical Name

8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-fluoro-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid hexasodium salt

CAS Number

104869-26-3

PubChem ID

71433548

InChI Key

QJFCMJZVZFAWGF-UHFFFAOYSA-H

SMILES

[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[O-]OOSC1=C2C(NC(=O)C3=CC(NC(=O)C4=CC(NC(=O)NC5=CC(=CC=C5)C(=O)NC5=CC(=CC=C5F)C(=O)NC5=CC=C(C6=CC(=CC(=C56)S([O-])(=O)=O)S([O-])(=O)=O)S([O-])(=O)=O)=CC=C4)=C(F)C=C3)=CC=C(C2=CC(=C1)S([O-])(=O)=O)S([O-])(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 5 4
DMSO 10 7

Preparing Stock Solutions for NF 157

The following data is based on the product molecular weight 1437.08.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.07 mM 9.94 mL 49.70 mL 99.41 mL
0.35 mM 1.99 mL 9.94 mL 19.88 mL
0.7 mM 0.99 mL 4.97 mL 9.94 mL
3.5 mM 0.20 mL 0.99 mL 1.99 mL

Calculators

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 49 publications citing the usage of this product.

Product Documents for NF 157

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for NF 157

For research use only

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