NF 279

Tocris Bioscience | Catalog # 1199

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Citations (49)

Product Documents

Potent and selective P2X1 antagonist

Product Description
Product Specifications
Solubility
Preparing Stock Solutions
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Potent and selective P2X1 antagonist

View all P2X Receptor Antagonists »

Product Description

NF 279 is a a potent and selective P2X₁ antagonist (IC₅₀ = 19 nM). Displays good selectivity over P2X₂,(IC₅₀ = 0.76 μM), P2X₃ (IC₅₀ = 1.62μM), P2X₄ (IC₅₀ > 300 μM), P2Y receptors and ecto-nucleotidases.

This product is supplied with a high degree of hydration and some residual NaCl, the amount of which are batch dependent. Please refer to the Certificate of Analysis to obtain the batch specific Net Product Content.

Product Specifications for NF 279

Molecular Weight

1401.10

Formula

C₄₉H₃₀N₆Na₆O₂₃S₆

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

8,8'-[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonic acid hexasodium salt

CAS Number

202983-32-2

PubChem ID

4467

InChI Key

RJMCMLNRWDKUDB-UHFFFAOYSA-H

SMILES

[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[O-]S(=O)(=O)C1=CC2=C(C(NC(=O)C3=CC=C(NC(=O)C4=CC=C(NC(=O)NC5=CC=C(C=C5)C(=O)NC5=CC=C(C=C5)C(=O)NC5=C6C(C=C(C=C6S([O-])(=O)=O)S([O-])(=O)=O)=C(C=C5)S([O-])(=O)=O)C=C4)C=C3)=CC=C2S([O-])(=O)=O)C(=C1)S([O-])(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	25	18

Preparing Stock Solutions for NF 279

The following data is based on the product molecular weight 1401.10.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.18 mM	3.97 mL	19.83 mL	39.65 mL
0.9 mM	0.79 mL	3.97 mL	7.93 mL
1.8 mM	0.40 mL	1.98 mL	3.97 mL
9 mM	0.08 mL	0.40 mL	0.79 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

音量

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 49 publications citing the usage of this product.

Klapperstuck Antagonism by the suramin analogue NF 279 on human P2X₁ and P2X₇ receptors. Eur.J.Pharmacol. 2000 PMID: 10650169
Rettinger The suramin analogue NF279 is a novel and potent antagonist selective for the P2X₁ receptor. Neuropharmacology 2000 PMID: 10963748
Damer NF279: a novel potent and selective antagonist of P2X receptor-mediated responses. Eur.J.Pharmacol. 1998 PMID: 9683026

Product Documents for NF 279

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for NF 279

For research use only

Citations for NF 279

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