NKH 477

Tocris Bioscience | Catalog # 1603

Water-soluble adenylyl cyclase activator
Tocris Bioscience

Key Product Details

Description

Water-soluble adenylyl cyclase activator

Alternative Names

Colforsin dapropate hydrochloride,6-(3-dimethylaminopropionyl)forskolin hydrochloride
View all Adenylyl Cyclase Activators »

Product Description

NKH 477 is a water-soluble analog of forskolin (Cat. No. 1099) that is a potent activator of adenylyl cyclase; shows some selectivity for cardiac (type V) adenylyl cyclase. Stimulates bronchodilation (EC50 = 32.6 nM) and is an orally active potent positive chronotrope and hypotensive agent in vivo.

Product Specifications for NKH 477

Molecular Weight

546.10

Formula

C27H43NO8.HCl

Storage

Desiccate at +4°C

Purity

≥98% (HPLC)

Chemical Name

N,N-Dimethyl-(3R,4aR,5S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-yl ester β-alanine hydrochloride

CAS Number

138605-00-2

PubChem ID

444028

InChI Key

VIRRLEDAYYYTOD-YHEOSNBFSA-N

SMILES

O=C(CCN(C)C)O[C@H]2[C@@]1([H])C(C)(C)CC[C@H](O)[C@@](C)1[C@]3(O)[C@@](O[C@](C=C)(C)CC3=O)(C)[C@H]2OC(C)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 21.84 40

Preparing Stock Solutions for NKH 477

The following data is based on the product molecular weight 546.10.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.4 mM 4.58 mL 22.89 mL 45.78 mL
2 mM 0.92 mL 4.58 mL 9.16 mL
4 mM 0.46 mL 2.29 mL 4.58 mL
20 mM 0.09 mL 0.46 mL 0.92 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 42 publications citing the usage of this product.

Product Documents for NKH 477

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for NKH 477

For research use only

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