Norovirus VP1 Antibody (A1227) - Chimeric - BSA Free

Novus Biologicals | Catalog # NBP3-43558

Recombinant Monoclonal Antibody
Novus Biologicals
100% Guarantee

Key Product Details

Species Reactivity

Virus

Applications

ELISA

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Mouse IgG1 Clone # A1227

Format

BSA Free
View all Norovirus VP1 Primary Antibodies »

Product Specifications

Immunogen

The original antibody was isolated from an anti-NoV GII.4c IgG serum antibody repertoire generated from three donors that experienced a significant increase in GII.4 titer after immunization with the bivalent GII.4c + GI.1 VLP vaccine. (Uniprot# Q83883)

Specificity

This antibody shows broadly binding but no blocking activity toward multiple GI and GII strains such as GI.I, GII.2, and GII.17. This antibody recognizes a highly conserved epitope located at an occluded site on the norovirus capsid, at the interface between the P domain and shell domain of the Norovirus, which explain its high level of cross-reactivity. Norovirus (NoVs) is one of the main pathogens causing sporadic cases and large outbreaks of acute gastroenteritis, and norovirus can infect people of all ages.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Description

This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG1 format for improved compatibility with existing reagents assays and techniques.

Scientific Data Images for Norovirus VP1 Antibody (A1227) - Chimeric - BSA Free

Norovirus VP1 Antibody (A1227) - Chimeric - BSA Free Norovirus VP1 Antibody (A1227) - Chimeric - BSA Free

ELISA: Norovirus VP1 Antibody (A1227) - Chimeric - BSA Free [NBP3-43558] -

ELISA: Norovirus VP1 Antibody (A1227) - Chimeric - BSA Free [NBP3-43558] - Binding curves of Norovirus VP1 (red) and an isotype control (anti-fluorescein; orange) on an ELISA plate coated with Norovirus VP1 at 2.5 µg/mL. A 3-fold serial dilution from 3,000 ng/mL to 0.0169 ng/mL was assessed. Detection was performed with an HRP-conjugated anti-rabbit IgG antibody (Goat Anti-Rabbit IgG, Fc-fragment specific, minimum cross-reactivity to human serum proteins) at 0.25 µg/mL.

Applications for Norovirus VP1 Antibody (A1227) - Chimeric - BSA Free

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Proclin 300

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Norovirus VP1

Alternate Names

Capsid Protein, Capsid protein VP1, CP, Norovirus Capsid protein VP1, Norwalk virus VP1, NoV VP1, p59

Additional Norovirus VP1 Products

Product Documents for Norovirus VP1 Antibody (A1227) - Chimeric - BSA Free

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Norovirus VP1 Antibody (A1227) - Chimeric - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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