NR 7h

Tocris Bioscience | Catalog # 7177

Potent and selective p38α and p38β Degrader (PROTAC®); active in vivo
Tocris Bioscience

Key Product Details

Description

Potent and selective p38α and p38β Degrader (PROTAC®); active in vivo
View all Active Degraders »

Product Description

NR 7h is a potent and selective p38α and p38β Degrader (PROTAC®) (DC50 < 50 nM). Displays no significant degradation of p38γ, p38δ, JNK1/2 or ERK1/2. Inhibits phosphorylation of MK2 in UV-treated cancer cells and LPS-stimulated bone marrow-derived macrophages (BMDM). Exhibits similar effect to p38α gene knockout in BBL358 cells. NR 7h impairs replication of Mayaro virus in human dermal fibroblasts and HeLa cells. Active in vivo.

p38α antibody validated for Simple Western™ (automated Western) instruments also available: Catalog # AF8691.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Licensing Information

Sold with kind permission of IRB Barcelona.

Product Specifications for NR 7h

Molecular Weight

998.87

Formula

C48H50BrF2N9O8

Storage

Store at -20°C

Purity

≥97% (HPLC)

Chemical Name

3-(3-Bromo-4-((2,4-difluorobenzyl)oxy)-6-methyl-2-oxopyridin-1(2H)-yl)-N-(4-(1-(4-((4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butyl)amino)-4-oxobutyl)-1H-1,2,3-triazol-4-yl)butyl)-4-methylbenzamide

CAS Number

2550399-06-7

InChI Key

BEMLUUUHZPFCBS-UHFFFAOYSA-N

SMILES

FC1=CC(F)=C(COC2=C(Br)C(N(C3=C(C)C=CC(C(NCCCCC4=CN(CCCC(NCCCCNC5=CC=CC(C(N6C7C(NC(CC7)=O)=O)=O)=C5C6=O)=O)N=N4)=O)=C3)C(C)=C2)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 99.89 100

Preparing Stock Solutions for NR 7h

The following data is based on the product molecular weight 998.87.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.00 mL 5.01 mL 10.01 mL
5 mM 0.20 mL 1.00 mL 2.00 mL
10 mM 0.10 mL 0.50 mL 1.00 mL
50 mM 0.02 mL 0.10 mL 0.20 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for NR 7h

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for NR 7h

For research use only

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