NS 309

Tocris Bioscience | Catalog # 3895

Positive modulator of KCa2 (SK) and KCa3.1 (IK) channels
Tocris Bioscience

Key Product Details

Description

Positive modulator of KCa2 (SK) and KCa3.1 (IK) channels
View all Ca2+-Activated Potassium Channel Activators »

Product Description

NS 309 is a positive modulator of small- and intermediate- conductance Ca2+-activated K+ channels (KCa2 and KCa3.1 channels); increases Ca2+ sensitivity. Displays no activity at BK channels.

Product Specifications for NS 309

Molecular Weight

231.04

Formula

C8H4Cl2N2O2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

6,7-Dichloro-1H-indole-2,3-dione 3-oxime

CAS Number

18711-16-5

PubChem ID

11637204

InChI Key

CVOUSAVHMDXCKG-UHFFFAOYSA-N

SMILES

ClC1=C2C(C(C(N2)=O)=NO)=CC=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.1 100

Preparing Stock Solutions for NS 309

The following data is based on the product molecular weight 231.04.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.33 mL 21.64 mL 43.28 mL
5 mM 0.87 mL 4.33 mL 8.66 mL
10 mM 0.43 mL 2.16 mL 4.33 mL
50 mM 0.09 mL 0.43 mL 0.87 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 58 publications citing the usage of this product.

Product Documents for NS 309

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for NS 309

For research use only

Related Research Areas

Ion Channels and Regulators

Customer Reviews for NS 309 (1)

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  • NS 309 worked nicely on experimental conditions
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 10/29/2018
    NS 309 is a potent Kca channel activator. I worked with 10,20,30,40,50,80,100 micrograms dissolved in DMSO. The product worked nicely in experimental conditions and would suggest to others researching Kca channel activation.
    NS 309 3895

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