NSC 617145

Key Product Details

Product Description

NSC 617145 is a werner syndrome helicase (WRN) helicase inhibitor (IC₅₀ = 250 nM); acts synergistically with Mitomycin C (Cat. No. 3258) to induce double-strand breaks and chromosomal abnormalities in vitro.

Product Specifications for NSC 617145

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for NSC 617145

The following data is based on the product molecular weight 400.04.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	12.50 mL	62.49 mL	124.99 mL
1 mM	2.50 mL	12.50 mL	25.00 mL
2 mM	1.25 mL	6.25 mL	12.50 mL
10 mM	0.25 mL	1.25 mL	2.50 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

• Aggarwal Targeting an Achilles' heel of cancer with a WRN helicase inhibitor. Cell Cycle 2013 PMID: 24036544
• Aggarwal Werner syndrome helicase has a critical role in DNA damage responses in the absence of a functional fanconi anemia pathway. Cancer Res. 2013 PMID: 23867477

Product Documents for NSC 617145