NSC 625987

Key Product Details

Product Description

NSC 625987 is a cyclin-dependent kinase (cdk) 4 inhibitor (IC₅₀ = 0.2 μM at cdk4/cyclin D1). Displays > 500-fold selectivity over cdk2 (IC₅₀ > 100 μM for cdc2/cyclin A, cdk2/cyclin A and cdk2/cyclin E).

Product Specifications for NSC 625987

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for NSC 625987

The following data is based on the product molecular weight 271.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.69 mL	18.43 mL	36.86 mL
5 mM	0.74 mL	3.69 mL	7.37 mL
10 mM	0.37 mL	1.84 mL	3.69 mL
50 mM	0.07 mL	0.37 mL	0.74 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• McInnes Structural determinants of CDK4 inhibition and design of selective ATP competitive inhibitors. Chem.Biol. 2004 PMID: 15123247
• Kubo The p16 status of tumor cell lines identifies small molecule inhibitors specific for cyclin-dependent kinase 4. Clin.Cancer Res. 1999 PMID: 10632371

Product Documents for NSC 625987