NU 7441

Tocris Bioscience | Catalog # 3712

Potent and selective DNA-PK inhibitor
Tocris Bioscience

Key Product Details

Description

Potent and selective DNA-PK inhibitor

Alternative Names

KU 57788
View all DNA-dependent Protein Kinase Inhibitors »

Product Description

NU 7441 is a potent and selective DNA-PK inhibitor (IC50 = 14 nM). Selective for DNA-PK over a range of kinases including mTOR, PI 3-K, ATM and ATR. Potentiates the effects of doxorubicin (Cat. No. 2252) and etoposide (Cat. No. 1226) in vitro and etoposide in vivo. Also enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency 2 to 3-fold, and decreases nonhomologous end-joining (NHEJ) frequency ~40%.

Product Specifications for NU 7441

Molecular Weight

413.49

Formula

C25H19NO3S

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one

CAS Number

503468-95-9

PubChem ID

11327430

InChI Key

JAMULYFATHSZJM-UHFFFAOYSA-N

SMILES

O=C1C3=C(C(C4=CC=CC5=C4SC6=C5C=CC=C6)=CC=C3)OC(N2CCOCC2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 2.07 5 with gentle warming

Preparing Stock Solutions for NU 7441

The following data is based on the product molecular weight 413.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 48.37 mL 241.84 mL 483.69 mL
0.25 mM 9.67 mL 48.37 mL 96.74 mL
0.5 mM 4.84 mL 24.18 mL 48.37 mL
2.5 mM 0.97 mL 4.84 mL 9.67 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 203 publications citing the usage of this product.

Product Documents for NU 7441

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for NU 7441

For research use only

Related Research Areas

DNA Repair

Customer Reviews for NU 7441 (1)

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  • Inhibition of NU 7441 results in DNA damage
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: hela
    Verified Customer | Posted 02/29/2020
    HeLa cells transfected with in vitro transcribed I-PpoI and treated or not with inhibitors for KU 55933 and NU 7441 (iDPK)
    NU 7441 3712

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