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NVP CXCR2 20

Catalog #: 5660 Datasheet / COA / SDS

Discontinued Product

5660 has been discontinued.
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NVP CXCR2 20 | CAS No. 1029521-30-9 | Chemokine Receptor Antagonists
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Description: Potent and selective CXCR2 antagonist

Chemical Name: 4-Cyclopropyl-2-[[(2,3-difluorophenyl)methyl]thio]-1,6-dihydro-6-oxo5-pyrimidinecarbonitrile

Purity: ≥98%

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Biological Activity

Potent and selective CXCR2 antagonist (IC50 = 40 nM). Exhibits selectivity for CXCR2 over a panel of 49 other GPCRs. Orally bioavailable.

Technical Data

M.Wt:
319.33
Formula:
C15H11F2N3OS
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1029521-30-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The discovery of potent, orally bioavailable pyrimidine-5-carbonitrile-6-alkyl CXCR2 receptor antagonists.
    Porter et al.
    Bioorg.Med.Chem.Lett., 2014;24:3285

Product Datasheets

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