NX 5948

Key Product Details

Product Description

NX 5948 is a potent and selective Bruton's tyrosine kinase (BTK) Degrader (PROTAC^®) (DC₅₀ = <1 nM; D_max = 98%). Comprises a BTK binding moiety joined by a linker to cereblon (CRBN) ligand. In vitro, NX-5948 very potently, rapidly and completely degrades BTK in primary human B cells (DC₅₀ = 0.034 nM). NX 5948 degrades BTK, inhibits tumor growth and increases survival in TMD8 xenograft mouse models of brain maligancy. Reduces inflammation and symptom severity in a mouse model of collagen-induced arthritis. NX 5948 is orally bioavailable and blood brain barrier penetrant.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Licensing Information

Sold under license from Nurix Therapeutics

Product Specifications for NX 5948

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for NX 5948

The following data is based on the product molecular weight 806.97.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	2.48 mL	12.39 mL	24.78 mL
2.5 mM	0.50 mL	2.48 mL	4.96 mL
5 mM	0.25 mL	1.24 mL	2.48 mL
25 mM	0.05 mL	0.25 mL	0.50 mL

Calculators

Background References

References are publications that support the biological activity of the product.

There are currently no references for this product.

Product Documents for NX 5948