PD 150606

Key Product Details

Product Description

PD 150606 is a selective, cell-permeable non-peptide calpain inhibitor (K_i values for ν and m-calpains are 0.21 and 0.37 μM respectively). Targets the calcium binding sites of calpain. Demonstrates high specificity for calpains relative to other proteases, and is a non-competitive inhibitor with respect to the substrate.

Product Specifications for PD 150606

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for PD 150606

The following data is based on the product molecular weight 306.12.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.27 mL	16.33 mL	32.67 mL
5 mM	0.65 mL	3.27 mL	6.53 mL
10 mM	0.33 mL	1.63 mL	3.27 mL
50 mM	0.07 mL	0.33 mL	0.65 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 23 publications citing the usage of this product.

• Wang An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective. Proc.Natl.Acad.Sci.U.S.A. 1996 PMID: 8692879
• Waters Calpains mediate calcium chloride influx during the late phase of cell injury. J.Pharmacol.Exp.Ther. 1997 PMID: 9399991
• Squier Calpain and calpastatin regulate neutrophil apoptosis. J.Cell Physiol. 1999 PMID: 9989777

Product Documents for PD 150606