PD 173074

Tocris Bioscience | Catalog # 3044

FGFR1 and -3 inhibitor
Tocris Bioscience

Key Product Details

Description

FGFR1 and -3 inhibitor
View all FGF Receptor Inhibitors »

Product Description

PD 173074 is a selective FGFR1 and FGFR3 inhibitor (IC50 values are 5, 21.5, ~100, 17600 and 19800 nM for FGFR3, FGFR1, VEGFR2, PDGFR and c-Src respectively, and > 50000 nM for EGFR, InsR, MEK and PKC). Inhibits VEGF- and FGF-induced angiogenesis in the mouse cornea model of angiogenesis. Inhibits proliferation and differentiation of oligodendrocyte progenitors. Also promotes mESC self-renewal, facilitates the conversion of mouse epiblast stem cells to an earlier pluripotency state and inhibits differentiation of miPSCs to cardiomyocytes. Suppresses cell proliferation in cell lines expressing mutated FGFR3 protein. Blocks tumor growth in H510 and H69 SCLC xenograft models.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for PD 173074

Molecular Weight

523.67

Formula

C28H41N7O3

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea

CAS Number

219580-11-7

PubChem ID

1401

InChI Key

DXCUKNQANPLTEJ-UHFFFAOYSA-N

SMILES

O=C(NC(C)(C)C)NC2=NC1=NC(NCCCCN(CC)CC)=NC=C1C=C2C3=CC(OC)=CC(OC)=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 52.37 100
Ethanol 52.37 100

Preparing Stock Solutions for PD 173074

The following data is based on the product molecular weight 523.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.91 mL 9.55 mL 19.10 mL
5 mM 0.38 mL 1.91 mL 3.82 mL
10 mM 0.19 mL 0.95 mL 1.91 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

Calculators

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Product Documents for PD 173074

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PD 173074

For research use only

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  • PD173074's ability to alter certain genes
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vivo
    Cell Line/Tissue: skin
    Verified Customer | Posted 06/29/2020
    Mouse primary fibroblasts also treat with PD173074 2 μM, vehicle: DMSO.
    Mice received a dose of 25 mg per kg body weight PD173074 dissolved in acetone or vehicle only topically onto the back skin.
    PD 173074 3044

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