Peptide5
Tocris Bioscience | Catalog # 6394
Connexin43 mimetic peptide
Discontinued Product
6394 has been discontinued.
View all Connexin 43/GJA1 products.
Product Description
Peptide5 is a connexin43 mimetic peptide. Reduces swelling, astrogliosis, neuroinflammation and neuronal cell death following spinal cord injury ex vivo and in vivo. Exhibits analgesic effects in models of neuropathic pain.
Product Specifications for Peptide5
Molecular Weight
1395.59
Formula
C60H98N16O20S
Storage
Store at -20°C
CAS Number
916977-43-0
PubChem ID
90693053
InChI Key
RJEAEIUDNCLZNN-VUZGFOMDSA-N
SMILES
[H]N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
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Solubility
| Solubility | Soluble to 2mg/ml in water |
Calculators
Background References
References are publications that support the biological activity of the product.
- Tonkin Attenuation of mechanical pain hypersensitivity by treatment with Peptide5, a connexin-43 mimetic peptide, involves inhibition of NLRP3 inflammasome in nerve-injured mice. Exp.Neurol. 2017 PMID: 29055716
- Mao Characterisation of Peptide5 systemic administration for treating traumatic spinal cord injured rats. Exp.Brain.Res. 2017 PMID: 28725925
- Kim Characterising the mode of action of extracellular Connexin43 channel mimetic peptides in an in vitro ischemia injury model. Biochem.Biophys.Acta. 2017 PMID: 27816754
- O'Carroll Connexin 43 mimetic peptides reduce swelling, astrogliosis and neuronal cell death after spinal cord injury. Cell.Commun.Adhes. 2008 PMID: 18649176
Product Documents for Peptide5
Certificate of Analysis
To download a Certificate of Analysis, please enter a lot or batch number in the search box below.
Product Specific Notices for Peptide5
For research use only
Related Research Areas
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