PF 04937319
Chemical Name: N,N-Dimethyl-5-[[2-methyl-6-[[(5-methyl-2-pyrazinyl)amino]carbonyl]-4-benzofuranyl]oxy]-2-pyrimidinecarboxamide
Purity: ≥98%
Biological Activity
PF 04937319 is a glucokinase partial activator (EC50 = 174 nM). Enhances glucose-stimulated insulin secretion in islet cell cultures and translocation of glucokinase from the nucleus to the cytoplasm in hepatocytes in vitro. Reduces post-prandial plasma glucose levels in an oral glucose tolerance test in rats.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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The relationship of glucokinase activator-induced hypoglycemia with arteriopathy, neuronal necrosis, and peripheral neuropathy in nonclinical studies.
Pettersen et al.
Toxicol. Pathol., 2014;42:696 -
Designing glucokinase activators with reduced hypoglycemia risk: discovery of N,N-dimethyl-5-(2-methyl-6-((5-methylpyrazin-2-yl)-carbamoyl)benzofuran-4-yloxy)pyrimidine-2-carboxamide as a clinical candidate for the treatment of type 2 di
Pfefferkorn et al.
Med.Chem.Commun.,, 2011;2:828
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