PhiKan 083

Key Product Details

Product Description

PhiKan 083 is a p53 stabilizing agent; preferentially binds mutated (Y220C) p53 over wild-type p53 at a site distinct from functional DNA/protein interaction regions. Slows rate of thermal denaturation of p53-Y220C.

Product Specifications for PhiKan 083

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for PhiKan 083

The following data is based on the product molecular weight 274.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.64 mL	18.20 mL	36.39 mL
5 mM	0.73 mL	3.64 mL	7.28 mL
10 mM	0.36 mL	1.82 mL	3.64 mL
50 mM	0.07 mL	0.36 mL	0.73 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

• Wiman Pharmacological reactivation of mutant p53: from protein structure to the cancer patient. Oncogene. 2010 PMID: 20498645
• Boeckler Targeted rescue of a destabilized mutant of p53 by an in silico screened drug. Proc.Natl.Acad.Sci. 2008 PMID: 18650397

Product Documents for PhiKan 083