Pifithrin-α hydrobromide

Tocris Bioscience | Catalog # 1267

p53 inhibitor. Also aryl hydrocarbon receptor agonist
Tocris Bioscience

Key Product Details

Description

p53 inhibitor. Also aryl hydrocarbon receptor agonist
View all p53 Inhibitors »

Product Description

Pifithrin-α hydrobromide is an inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorders. Active in vivo; protects mice from the side-effects of cancer therapy associated with p53 induction. Supresses self-renewal of embryonic stem cells. Also aryl hydrocarbon receptor (AHR) agonist, causes upregulation of AHR target gene CYP1A1 (EC50 = 1.1 μM). Cyclic analog available (Cat. No. 3843).

Product Specifications for Pifithrin-α hydrobromide

Molecular Weight

367.30

Formula

C16H18N2OS.HBr

Storage

Desiccate at -20°C

Chemical Name

1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone hydrobromide

CAS Number

63208-82-2

PubChem ID

9929138

InChI Key

HAGVCKULCLQGRF-UHFFFAOYSA-N

SMILES

Br.CC1=CC=C(C=C1)C(=O)CN1C(=N)SC2=C1CCCC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.73 100

Preparing Stock Solutions for Pifithrin-α hydrobromide

The following data is based on the product molecular weight 367.30.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.72 mL 13.61 mL 27.23 mL
5 mM 0.54 mL 2.72 mL 5.45 mL
10 mM 0.27 mL 1.36 mL 2.72 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 13 publications citing the usage of this product.

Product Documents for Pifithrin-α hydrobromide

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Pifithrin-α hydrobromide

For research use only

Citations for Pifithrin-α hydrobromide

Customer Reviews for Pifithrin-α hydrobromide (3)

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  • Study of the effects of p53 inhibition in chemotherapy-induced apoptosis of human cancer cells.
    Name: MARINA KOUTSIOUMPA
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 06/10/2021
    The inhibitor worked nicely, and the results were consistent. We are happy with the quality of the product.
  • Pifithrin-alpha
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vivo
    Cell Line/Tissue: neural cell
    Verified Customer | Posted 07/12/2020
    Pifithrin-alpha were dissolved in DMSO and used at a final concentration of 40 µM for pifithrin-alpha according to previous studies in which 3-100 µM pifithrin-alpha.
    Pifithrin-α hydrobromide 1267
  • The effect of p53 loss in human lung cancer cell lines.
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 01/04/2018
    We are happy with the quality of the product and the assistance from the Tocris technical department. All our questions about the use of the product where answered within a few hours.
    We used the p53 inhibitor in order to tackle the p53 protein in-vitro for some cellular proliferation assays,

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