PPQ 102

Tocris Bioscience | Catalog # 4303

Potent, voltage-independent CFTR chloride channel inhibitor
Tocris Bioscience
Discontinued Product
4303 has been discontinued. View all CFTR Blockers products.

Key Product Details

Description

Potent, voltage-independent CFTR chloride channel inhibitor
View all CFTR Blockers »

Product Description

PPQ 102 is a potent, voltage-independent CFTR chloride channel inhibitor (IC50 = 90 nM). Reduces the size and number of renal cysts in an embryonic kidney culture model of polycystic kidney disease. Also increases VEGF-A production from airway epithelial cells in vitro.

Product Specifications for PPQ 102

Molecular Weight

438.48

Formula

C26H22N4O3

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

6,7-Dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenylpyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione

CAS Number

931706-15-9

PubChem ID

16016583

InChI Key

MNOOVRNGPIWJDI-UHFFFAOYSA-N

SMILES

O=C(N2C)C1=C(C3=CC=CC=C3)N4C(C(C6=CC=C(C)O6)NC5=C4C=CC=C5)=C1N(C)C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 8.77 20 with gentle warming

Preparing Stock Solutions for PPQ 102

The following data is based on the product molecular weight 438.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 11.40 mL 57.02 mL 114.03 mL
1 mM 2.28 mL 11.40 mL 22.81 mL
2 mM 1.14 mL 5.70 mL 11.40 mL
10 mM 0.23 mL 1.14 mL 2.28 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

Product Documents for PPQ 102

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PPQ 102

For research use only

Customer Reviews for PPQ 102 (1)

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  • PPQ 102 inhibited of CFTR chloride current was studied
    Name: Lutpine Rachel
    Species: Human
    Verified Customer | Posted 01/16/2020
    PPQ-102 inhibited of CFTR chloride current was studied.Patch-clamp analysis confirmed voltage-independent CFTR inhibition by PPQ-102 and showed stabilization of the channel closed state.
    PPQ 102 4303

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